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A prospective evaluation of lung functionin infants with PPHN treated with/without iNOwas reported by Dobyns and colleagues (1999):compared to healthy control infants of the sameage, there were no differences in lung volume orpassive respiratory mechanics for infants withPPHN, nor was there any effect of iNO on laterpulmonary function in the PPHN group. The pain is dull in nature,intermittent, more marked in the morning after waking from sleep, not associated with nausea orvomiting.
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